Mechanism of action of SHCBP1 in malignant tumors and progress in clinical research
10.3760/cma.j.cn371439-20250331-00098
- VernacularTitle:SHCBP1在恶性肿瘤中的作用机制及临床研究进展
- Author:
Mei LIU
1
;
Yuchong HU
;
Fengtong LI
;
Lemen CHAO
;
Meng LIU
;
Linlin KANG
Author Information
1. 内蒙古医科大学内蒙古临床学院，呼和浩特 010017
- Keywords:
Neoplasms;
Src homology 2 domain-containing, transforming protein 1;
Cell proliferation;
Cell movement;
Tumor microenvironment;
Prognosis
- From:
Journal of International Oncology
2025;52(9):583-586
- CountryChina
- Language:Chinese
-
Abstract:
SHCBP1 is a type of Src homologous collagen that can specifically bind to the SH2 structural domain. It can act as a key regulatory protein, and exhibits abnormally high expression in a variety of malignant tumors. Through affecting the processes such as cell cycle, proliferation, and invasion, it participates in tumor genesis and development. In addition, high expression of SHCBP1 is closely related to chemotherapy resistance and poor prognosis of many malignant tumors, and its targeted inhibition can enhance the sensitivity of chemotherapy and provide new therapeutic strategies for a variety of solid tumors, making it an important biomarker for prognostic assessment and a potential therapeutic target.
