Research progress of RNA m 6A modification in breast cancer

VernacularTitle:RNA m 6A修饰在乳腺癌中的研究进展
Author: Junlong GUO ¹ ; Ruiqi ZOU ; Shaoqiang CHEN ; Yuxin LIANG ; Jing LI ; Sunan YONG ; Yuting HE ; Xiaobing XIE ; Ping LI
Author Information

1. 湖南中医药大学第一附属医院医学检验中心，长沙　410007
Keywords: Breast neoplasms; Epigenomics; N 6-methyladenosine
From: Journal of International Oncology 2025;52(8):532-537
CountryChina
Language:Chinese
Abstract: Breast cancer is one of the most common malignant tumors among women worldwide, with an increasing incidence rate year by year, making it a significant public health concern. With the continuous advancement of tumor biology research, N 6-methyladenosine (m 6A) modification, as an important form of RNA modification, has attracted growing attention. The m 6A modification, the most prevalent RNA modification in eukaryotes, occurs in almost all types of RNA and plays a critical role in the occurrence, progression, and metastasis of breast cancer. It influences cell proliferation, apoptosis, and alterations in the tumor microenvironment, though the specific mechanisms underlying these effects require further in-depth investigation. Moreover, the specific patterns of m 6A modification demonstrate its potential as a novel biomarker for breast cancer, which could provide new directions for early diagnosis and prognosis evaluation.