Clinical applications of TCR sequencing in cancer immunotherapy

VernacularTitle:TCR测序在肿瘤免疫治疗中的临床应用
Author: Xuehui WU ¹ ; Song LI ; Lian LIU
Author Information

1. 山东大学齐鲁医院肿瘤内科，济南　250012
Keywords: Immunotherapy; T cell receptor; High-throughput sequencing
From: Journal of International Oncology 2025;52(8):523-527
CountryChina
Language:Chinese
Abstract: T cell receptor (TCR) is a key molecule mediating anti-tumor immunity, and its diversity profile (TCR repertoire) serves as a biomarker of host immune status. The development of high-throughput sequencing technologies has revolutionized the application of TCR repertoire analysis in cancer immunotherapy. The clinical value of TCR sequencing in individualized tumor treatment is increasingly prominent. Through monitoring immunotherapy response and predicting survival outcomes, TCR sequencing provides critical guidance for precision tumor therapy.