Progress of pathogenesis and clinical research on immunotherapy for peritoneal carcinomatosis
10.3760/cma.j.cn371439-20250106-00055
- VernacularTitle:腹膜转移癌的发病机制与免疫治疗临床研究进展
- Author:
Chunwang JI
1
;
Song LI
;
Lian LIU
Author Information
1. 山东大学第一临床学院，济南 250100
- Keywords:
Peritoneal carcinomatosis;
Immune microenvironment;
Immune checkpoint inhibitor;
Cell therapy;
Combination therapy
- From:
Journal of International Oncology
2025;52(5):325-330
- CountryChina
- Language:Chinese
-
Abstract:
Peritoneal carcinomatosis is a common manifestation of advanced malignant tumors. Its complex pathological features and unique immunosuppressive microenvironment limit the effectiveness of traditional treatment. At present, immunotherapy for peritoneal carcinomatosis shows certain potential, but still faces many challenges. Future research should focus on the development of new immunotherapy targets, the combination of local and systemic drug delivery approaches, the characterization of the tumor microenvironment using single-cell genomics and spatial transcriptome technologies, and the screening of appropriate populations using artificial intelligence, which is expected to effectively improve patient survival.
