Role and research progress of ferroptosis in colorectal cancer

VernacularTitle:铁死亡在结直肠癌中的作用及研究进展
Author: Haiyang GUO ¹ ; Yonggang HONG ; Liqiang HAO
Author Information

1. 海军军医大学第一附属医院肛肠外科，上海　200433
Keywords: Colorectal neoplasms; Ferroptosis; Antineoplastic protocols; Ferroptosis-related gene
From: Journal of International Oncology 2025;52(5):319-324
CountryChina
Language:Chinese
Abstract: Colorectal cancer (CRC) is one of the most prevalent malignant tumors of the digestive system worldwide, characterized by continuously rising incidence and mortality rates. Despite significant advancements in therapeutic approaches, the prognosis for advanced-stage CRC remains unsatisfactory, highlighting the urgent need to explore novel molecular mechanisms and therapeutic strategies. Ferroptosis, a form of programmed cell death driven by iron-dependent lipid peroxidation, plays a crucial role in cancer occurrence, progression, and treatment resistance. Activation of ferroptosis significantly suppresses tumor cell growth. Further investigation into the mechanisms of ferroptosis in CRC occurrence, progression, and treatment could provide valuable insights for both basic and clinical research on CRC.