Advances in aptamers screening and the applications in cancer therapy

VernacularTitle:适配体筛选技术及其在肿瘤治疗中的研究进展
Author: Siqi ZHENG ¹ ; Ting GUO ; Jing WANG ; Yinghong TIAN ; Xingmei ZHANG
Author Information

1. 南方医科大学基础医学院神经生物学教研室，广州　510515
Keywords: Aptamer; SELEX aptamer technique; Antineoplastic protocols
From: Journal of International Oncology 2025;52(5):304-308
CountryChina
Language:Chinese
Abstract: Aptamers are a class of short DNA/RNA single strand oligonucleotides that can bind to target molecules with high affinity specificity. They have the advantages of high affinity specificity, low molecular weight and low immunogenicity, and have been widely used in biomedical research, clinical diagnosis and therapy, and biosensor development. Systematic evolution of ligand by exponential enrichment (SELEX) is an in vitro screening technique, which enriches the aptamers with high affinity and specific binding to the target through multiple cycles of screening, and has a wide range of applications in tumor therapy.