Research progress of copper death in tumor
10.3760/cma.j.cn371439-20240727-00025
- VernacularTitle:铜死亡在肿瘤中的研究进展
- Author:
Zhiyuan LI
1
;
Xiuhong JIA
Author Information
1. 滨州医学院附属医院儿科，滨州 256603
- Keywords:
Neoplasms;
Cell death;
Copper death
- From:
Journal of International Oncology
2025;52(3):163-168
- CountryChina
- Language:Chinese
-
Abstract:
Copper death is a newly discovered copper-dependent cell death mode that causes protein-toxic stress and triggers cell death by affecting mitochondrial tricarboxylic acid cycling and iron-sulfur tuftin loss. In recent years, with the in-depth study of the mechanism of copper death, it has been found that the genes related to copper death may be related to the clinical characteristics and prognosis of tumors, which can be used as potential biological targets for the diagnosis or treatment of tumors. At the same time, drugs targeting copper ions such as copper ionophores, copper chelators and copper containing complexes are widely studied. Further study on the mechanism of copper death in the development of tumor can provide new ideas for tumor diagnosis and treatment.
