Research progress of clock gene Period family in head and neck squamous cell carcinoma
10.3760/cma.j.cn371439-20240927-00017
- VernacularTitle:时钟基因Period家族在头颈鳞状细胞癌中的研究进展
- Author:
Yongying YE
1
;
Yan ZOU
;
Tianming CHEN
;
Weili WU
Author Information
1. 贵州医科大学临床医学院肿瘤学教研室，贵阳 550000
- Keywords:
Squamous cell carcinoma of head and neck;
Prognosis;
Molecular targeted therapy;
Tumor microenvironment;
Period gene
- From:
Journal of International Oncology
2025;52(2):113-118
- CountryChina
- Language:Chinese
-
Abstract:
Head and neck squamous cell carcinoma (HNSCC) is the most common type of heterogeneous malignant tumor. Over 60% of HNSCC patients are at locally advanced stage at the time of diagnosis. Despite the emergence of advanced diagnosis and treatment measures, the prognosis of patients with recurrent or metastatic HNSCC remains poor. The Period (PER) gene family is an important member of the circadian clock genes, with family members PER1, PER2, and PER3 showing differential expression in HNSCC, participating in biological processes such as proliferation, apoptosis, invasion, or metastasis of tumor cells. In most studies, they exhibit anti-cancer effects and are closely related to the tumor microenvironment, immunotherapy, chronotherapy, etc., making them potential biomarkers. A comprehensive analysis of the expression of PER gene family in HNSCC, its biological role in the occurrence and development of tumor and the corresponding molecular biological mechanism is helpful to explore its potential application value in the diagnosis and treatment of HNSCC.
