Mechanism of Breg cell in tumor immune escape and related therapeutic targets
10.3760/cma.j.cn371439-20240522-00016
- VernacularTitle:Breg细胞在肿瘤免疫逃逸中的机制及相关治疗靶点
- Author:
Xibo WANG
1
;
Baowen TIAN
;
Shiqiao CHEN
Author Information
1. 山东大学附属山东省立医院，济南 250021
- Keywords:
B-lymphocytes, regulatory;
Tumor microenvironment;
Cytokines;
T-lymphocytes;
Immunotherapy
- From:
Journal of International Oncology
2025;52(2):107-112
- CountryChina
- Language:Chinese
-
Abstract:
Tumor cells can escape the surveillance and attack of the immune system, namely immune escape. In recent years, regulatory B (Breg) cell have attracted much attention in researches about tumor immunity. Breg cell plays an important role in tumor immune escape by secreted various cytokines. Mechanistic progress has been made in this field, which provides more targets and ideas for tumor clinical treatment. However, the phenotypic classification of Breg cells and its complex mechanism in tumor immunity still need to be systematically analyzed.
