Mechanism of action and clinical significance of circular RNA in triple negative breast cancer
10.3760/cma.j.cn371439-20240702-00131
- VernacularTitle:环状RNA在三阴性乳腺癌中的作用机制及临床意义
- Author:
Li WANG
1
;
Han XIAO
;
Guofu HUANG
Author Information
1. 新疆医科大学第五附属医院肿瘤科，乌鲁木齐 830000
- Keywords:
Triple negative breast neoplasms;
RNA, circular;
Carcinogenesis;
Biological therapy
- From:
Journal of International Oncology
2024;51(12):774-778
- CountryChina
- Language:Chinese
-
Abstract:
Circular RNA (circRNA) has shown great application potential in triple-negative breast cancer (TNBC). The aberrantly expressed circRNAs participate in the occurrence and development of TNBC by acting as microRNA sponges, regulating gene expression, interacting with functional proteins, and encoding short peptides or proteins to regulate the biological processes of TNBC cell proliferation, apoptosis, invasion, metastasis, and drug resistance. circRNAs are emerging biomarkers for early diagnosis and prognosis of TNBC, as well as new therapeutic targets with potential clinical value. Further elucidation of the complex mechanism of circRNAs in TNBC may provide an important theoretical basis for the development of precise therapeutic strategies for TNBC.
