Protein S-palmitoylation and its role in tumor
10.3760/cma.j.cn371439-20240522-00130
- VernacularTitle:蛋白S-棕榈酰化修饰及其在肿瘤中的作用
- Author:
Liang CHEN
1
;
Yingge LI
;
Sihao ZHENG
;
Cai ZHANG
;
Qilu YAN
;
Qibin SONG
;
Yi YAO
Author Information
1. 武汉大学人民医院肿瘤中心，武汉 430060
- Keywords:
Neoplasms;
Protein processing, post-translational;
S-palmitoylation;
Palmitoyltransfe-rases;
Acyl-protein thioesterases
- From:
Journal of International Oncology
2024;51(12):769-773
- CountryChina
- Language:Chinese
-
Abstract:
Protein S-palmitoylation is a reversible post-translational modification of lipids that regulates protein localization, stability and protein-protein interactions. The thioesterification of palmitate to internal cysteine residues is catalyzed by palmitoyltransferase, while the removal of palmitate is mainly catalyzed by acyl-protein thioesterase. The S-palmitoylation of some tumor-related proteins is abnormally altered in tumor, which is closely related to the biological processes such as tumor cell proliferation, invasion, metastasis, drug resistance and immune response. Furtherly, exploring the characteristics of protein S-palmitoy-lation and its role in tumor progression could deliver new ideas in targeting protein S-palmitoylation for tumor therapy.
