Role of CMTM6 and CMTM4 protein in tumorigenesis, development and prognosis

VernacularTitle:CMTM6和CMTM4在肿瘤发生、发展及预后中的作用
Author: Mingzhu MA ¹ ; Xiaoling GAO
Author Information

1. 山西医科大学第二临床医学院，太原　030000
Keywords: CMTM6; CMTM4; Neoplasms; Drug resistance
From: Journal of International Oncology 2024;51(11):706-711
CountryChina
Language:Chinese
Abstract: The CKLF-like MARVEL transmembrane domain containing family of genes (CMTM) family plays a crucial role in tumorigenesis, development, metastasis, and drug resistance. CMTM6 and CMTM4 are key proteins that regulate the stability of programmed death-ligand 1 (PD-L1) and play an important role in tumor immunotherapy resistance in particular. At present, the detailed molecular mechanisms linking CMTM6 and CMTM4 with tumors have not been fully understood. In-depth study of the expression, biological role and regulatory mechanism of CMTM4 and CMTM6 in tumors will provide new ideas and targets for the diagnosis, treatment and prediction of prognosis of tumors.