Research progress of lactate modification in vascular related diseases
10.3760/cma.j.cn115396-20250314-0005
- VernacularTitle:乳酸化修饰在血管相关疾病中的研究进展
- Author:
Xiao XU
1
;
Xiaohu GE
Author Information
1. 新疆医科大学研究生院，乌鲁木齐 830001
- Keywords:
Lactate;
Lactylation;
Post-translational modification;
Vascular diseases;
Atherosclerosis;
Vascular calcification;
Pulmonary hypertension
- From:
International Journal of Surgery
2025;52(11):781-785
- CountryChina
- Language:Chinese
-
Abstract:
The pathway by which cells obtain energy is inconsistent in aerobic and anaerobic conditions, glucose enters the cell and is converted into pyruvate by glycolysis under the action of hexokinase. When oxygen is sufficient, pyruvate enters the mitochondrial matrix and is converted into acetyl-CoA under the action of pyruvate dehydrogenase to participate in the tricarboxylic acid cycle and ultimately produce the necessary energy support for cell activities. When the cells are in an hypoxic state, pyruvate can produce lactic acid under the action of lactate dehydrogenase, and then carry out the corresponding cell activities after being energized. In recent years, advances in scientific research have elucidated that lactate serves not only as a crucial energy source, directly participating in metabolic processes such as mitochondrial respiration, but also plays critical roles in various physiological and pathological processes, including the regulation of inflammation, tissue repair, memory formation, and neuroprotection. These multifaceted functions further influence the onset, progression, and prognosis of diseases, thereby underscoring the broad regulatory significance of lactate in organismal physiology. Lactic acid modification is also associated with the occurrence and development of vascular related diseases, including changes in vascular endothelial microenvironment, lactic acid accumulation after thrombosis and inflammation, promotion of vascular endothelial microenvironment hypoxia, and lactic acid stimulation of vascular endothelial cells to produce inflammatory response. Clarifying the relationship between lactate modification and vaso-related diseases may help to reveal the underlying mechanism of disease occurrence and development. This article reviews the relationship between Lactylation and vascular related diseases, aiming to provide new targets and references for the treatment of vascular related diseases.
