Role and clinical significance of CST1 in digestive system neoplasms
10.3760/cma.j.cn115396-20250410-00086
- VernacularTitle:CST1在消化系统肿瘤中的作用及临床意义
- Author:
Yibin CHEN
1
;
Yuxuan ZHANG
;
Binwei DUAN
;
Mengcheng LIU
;
Guangming LI
;
Yabo OUYANG
Author Information
1. 首都医科大学附属北京佑安医院普通外科中心 北京肝病研究所，北京 100069
- Keywords:
Digestive system neoplasms;
Gene expression;
Reviews;
Cystatin 1;
Molecular mechanism;
Clinical significance
- From:
International Journal of Surgery
2025;52(9):643-648
- CountryChina
- Language:Chinese
-
Abstract:
Cysteine protease inhibitor SN(Cystatin SN , CST1), a member of the type 2 cystatins superfamily, regulates tumor biological activities by modulating cysteine protease activity. CST1 is abnormally expressed in digestive system neoplasms, such as esophageal cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, and pancreatic cancer. CST1 influences tumor cell proliferation, migration, and epithelial-mesenchymal transition (EMT) through signaling pathways including Wnt, STAT3, and PI3K-AKT. Its expression levels significantly correlated with tumor stage, metastasis, and patient prognosis, suggesting its potiential as a novel biomarker for early diagnosis, therapeutic evaluation, and prognosis in digestive system neoplasms. This article systematically reviews the molecular characteristics of CST1, its mechanisms of action in digestive system neoplasms, clinical significance, and explores its potential as a therapeutic target.
