New understanding of the relationship between FCHO1 and human disease
10.3760/cma.j.cn115396-20250424-00111
- VernacularTitle:FCHO1与人类疾病关系的新认识
- Author:
Youlei ZHANG
1
;
Zhen TIAN
;
Jie WANG
;
Yifan CHEN
;
Wen GU
;
Daorong WANG
Author Information
1. 扬州大学附属苏北人民医院胃肠外科，扬州 225001
- Keywords:
Endocytosis;
Immunologic deficiency syndromes;
Cardiovascular diseases;
FCH domain only 1 protein, Human;
Cancer;
Degenerative diseases, nervous system
- From:
International Journal of Surgery
2025;52(9):630-637
- CountryChina
- Language:Chinese
-
Abstract:
The FCHO1 protein, encoded by the FCHO1 gene, is a pioneer protein that plays an important role in the initial stage of clathrin-mediated endocytosis. In recent years, it has been found that defects in the FCHO1 gene or abnormal expression levels of the FCHO1 protein are closely related to certain human diseases. This article will review the latest research results of FCHO1 in malignant tumors, immunodeficiency diseases, neurodegenerative diseases of the nervous system, and cardiovascular diseases, providing a theoretical basis for the development of new targets for the diagnosis and treatment of related diseases.
