Advances in molecular mechanisms of gastric cancer invasion and metastasis
10.3760/cma.j.cn115396-20250423-00110
- VernacularTitle:胃癌侵袭和转移分子机制的研究进展
- Author:
Feilong WENG
1
;
Kekang SUN
Author Information
1. 江苏大学附属昆山医院胃肠外科，苏州 215300
- Keywords:
Stomach neoplasms;
Neoplasm invasiveness;
Neoplasm metastasis
- From:
International Journal of Surgery
2025;52(9):622-629
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer is one of the most common malignancies worldwide. The capacity for invasion and metastasis, as well as high heterogeneity, are the main reasons that gastric cancer patients lose the opportunity for surgery and have a poor prognosis. Despite the rapid advancement of molecular targeted therapies, such as HER2 and immune checkpoint inhibitors, survival of gastric cancer patients is still unsatisfactory because the understanding of the mechanism of gastric cancer progression is still incomplete. Recently, genomic research has critically deepened our knowledge of which gene products are dysregulated in invasive gastric cancer. Furthermore, the study of the interaction of gastric cancer cells with the tumor microenvironment has emerged as a principal subject in driving invasion and metastasis. These results are expected to provide a profound knowledge of how biological molecules are implicated in gastric cancer development. This review will summarize the advances in our current understanding of the molecular mechanism of gastric cancer invasion. Compared to conventional therapy using protease or molecular inhibitors alone, multi-therapy targeting invasion plasticity may seem to be an assuring direction for the progression of novel strategies.
