Advances in the diagnosis and treatment of pancreatic ductal adenocarcinoma
10.3760/cma.j.cn115396-20250520-00129
- VernacularTitle:胰腺导管腺癌的诊治进展
- Author:
Li ZHANG
1
;
Hangyan WANG
;
Dianrong XIU
Author Information
1. 北京大学第三医院普通外科，北京 100191
- Keywords:
Early diagnosis;
Surgical procedures, operative;
Postoperative complications;
Pancreatic ductal adenocarcinoma;
Pancreatic fistula;
Neoadjuvant therapy;
Tar
- From:
International Journal of Surgery
2025;52(6):361-365
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is a major disease that threatens human health, and its diagnosis and treatment remain significant challenges. However, with the continuous development of precision screening, minimally invasive surgery, comprehensive treatment, and emerging technologies, the diagnosis and treatment outcomes of PDAC are gradually improving, and there is hope for further increasing patient survival rates and quality of life in the future. Precisive screening for high-risk populations is of great significance for the early diagnosis of PDAC. The comprehensive application of diabetes history, tumor markers, imaging examinations, and artificial intelligence technology can aid in early detection. In terms of surgical treatment, the safety of PDAC surgery has significantly improved, with a substantial reduction in perioperative mortality. The widespread adoption of minimally invasive techniques allows complex surgeries to be performed safely, resulting in faster postoperative recovery. Pancreatic fistula, a common complication after pancreatic surgery, still has limitations in its definition and grading. However, ongoing research and technological improvements are helping to better prevent and manage this issue. In terms of comprehensive treatment, the popularization and improved efficacy of neoadjuvant chemotherapy, targeted therapy research focusing on KRAS mutations, and the development of cancer vaccines offer new hope for improving treatment outcomes. This article provides a comprehensive review of the advancements in early diagnostic methods, surgery, and integrated treatment strategies for PDAC.
