Progress in clinical research on gut microbiota related to obesity
10.3760/cma.j.cn115396-20250326-00071
- VernacularTitle:肥胖与肠道菌群的临床研究进展
- Author:
Linwei LI
1
;
Luyao LIU
;
Chen WANG
;
Jianzhong DI
Author Information
1. 上海交通大学医学院附属第六人民医院减重代谢外科，上海 201103
- Keywords:
Obesity;
Gastrointestinal microbiome;
Bariatric surgery;
Prebiotics;
Probiotics
- From:
International Journal of Surgery
2025;52(5):354-360
- CountryChina
- Language:Chinese
-
Abstract:
The gut microbiota plays a crucial role in regulating energy metabolism and obesity progression through mechanisms involving short-chain fatty acid and bile acid metabolism pathways. Obese individuals often exhibit gut microbiota dysbiosis, which can influence lipid metabolism and insulin sensitivity through microbial metabolites and signaling mechanisms. Dietary, pharmaceutical, and bariatric metabolism surgery can modulate the gut microbial, strongly correlating with weight reduction and metabolic benefits. Emerging microbiome-modulating strategies, such as probiotics, prebiotics, synbiotics, and fecal microbiota transplantation, can restore microbial homeostasis and improve bile acid processing, but results differ among people. Moreover, the structural specificity of dietary fibers enables targeted microbial modulation, which provide new perspectives for developing anti-obesity therapies. This review summarizes the mechanisms of interaction between gut microbiota and the host and the clinical research progress in obesity intervention.
