Metabolic and bariatric surgery′s historical progression and transformative shifts induced by GLP-1 receptor agonists

VernacularTitle:减重代谢手术历史演进与GLP-1RA带来的变革
Author: Zijie XU ¹ ; Ruiqi LI ; Shuai ZHAO ; Yayan FU ; Wei WANG ; Daorong WANG
Author Information

1. 南京大学医学院教学医院苏北人民医院，扬州　225001
Keywords: Obesity; Bariatric Medicine; Bariatric Surgery; Glucagon-Like Peptide 1
From: International Journal of Surgery 2025;52(5):296-301
CountryChina
Language:Chinese
Abstract: With obesity rates climbing worldwide, metabolic and bariatric surgery has evolved over seven decades into a pivotal therapeutic approach for treating severe obesity and related disorders. Recent research highlights that new anti-diabetic and weight-loss drugs, especially GLP-1 receptor agonists (GLP-1 RA), are catalyzing a paradigm shift in obesity management. Within this context, the key scientific challenge in metabolic surgery is thoroughly investigating how pharmacological interventions and surgical procedures work together in weight management, especially evaluating if new drugs can match bariatric surgery's long-term effectiveness, complication management, and metabolic changes. Resolving this interdisciplinary debate will influence precision medicine in obesity treatment and reshape future multidisciplinary care models for metabolic disorders.