Research progress on the correlation between angiopoietin-like protein 2 and lower extremity arteriosclerosis obliterans
10.3760/cma.j.cn115396-20240801-00245
- VernacularTitle:血管生成素样蛋白2与下肢动脉硬化闭塞症的相关性研究进展
- Author:
Yizhou LIU
1
;
Xuezhen CHAI
;
Zebin YU
;
Yue LIANG
Author Information
1. 内蒙古医科大学研究生院，呼和浩特 010110
- Keywords:
Lower extremity;
Arteriosclerosis obliterans;
Inflammation;
Atherosclerosis;
Angiopoietin-like protein 2
- From:
International Journal of Surgery
2025;52(3):199-204
- CountryChina
- Language:Chinese
-
Abstract:
Lower extremity arteriosclerosis obliterans(LEASO) is a disease in which systemic atherosclerosis affects the blood-supplying arteries of the lower extremities, resulting in chronic ischemia of the lower extremities. Angiopoietin-like protein 2(Angptl2) is a newly discovered pro-inflammatory protein that promotes the development of atherosclerosis by inducing vascular inflammatory responses. It is closely associated with certain risk factors for LEASO, such as advanced age, obesity, and type 2 diabetes. In addition, the high expression of Angptl2 in LEASO correlates with the continued progression of LEASO and may reflect the severity of the disease, suggesting that Angptl2 may be an important serologic biomarker for LEASO. In this article, we review the progress of research on the correlation between Angptl2 and LEASO, and analyze the value of Angptl2 as a biomarker for LEASO.
