Application and prospect of mesenchymal stem cells in orthopedic treatment

VernacularTitle:间充质干细胞在骨科治疗中的应用与前景
Author: Shang GUO ¹ ; Shutao ZHANG ; Zhongmin SHI
Author Information

1. 上海交通大学医学院附属第六人民医院骨科-足踝外科，上海　200233
Keywords: Mesenchymal stem cells; Tendon injuries; Bone regeneration
From: International Journal of Surgery 2025;52(3):145-150
CountryChina
Language:Chinese
Abstract: Mesenchymal stem cells(MSCs) are multipotent stem cells with the ability to self-renew and differentiate into multiple lineages. In recent years, MSCs have been increasingly used as a therapeutic strategy in orthopedic diseases such as osteoarthritis, rheumatoid arthritis, cartilage damage, tendon bone damage, bone defects, and degenerative bone diseases. Compared with cell-free therapy, MSCs have achieved better results. However, due to their widespread sources, complex action mechanisms, and diverse product types, there are certain limitations and controversies in their clinical application in orthopedics. This article will discuss the current main applications and future trends of MSCs in the field of orthopedics, looking forward to the prospects of MSCs application in orthopedics.