Research progress on mesenchymal stem cells-derived exosomes for the treatment of hepatocellular carcinoma
10.3760/cma.j.cn115396-20240920-00287
- VernacularTitle:间充质干细胞源性外泌体治疗肝细胞癌的研究进展
- Author:
Xueqing FENG
1
;
Jin LEI
;
Haiyang LI
Author Information
1. 贵州医科大学附属医院肝胆外科 贵州医科大学肝胆胰疾病治疗与生物信息学研究重点实验室，贵阳 550004
- Keywords:
Carcinoma, hepatocellular;
Stem cells;
Therapeutic uses;
Mesenchymal stem cell;
Exosomes
- From:
International Journal of Surgery
2024;51(12):859-864
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma is one of the most common malignant tumors, with early onset being stealthy, poor sensitivity to chemotherapy, poor prognosis, and high recurrence and mortality rates. In recent years, exosomes have emerged as a promising new treatment strategy for hepatocellular carcinoma in the exploration of various novel treatments. Mesenchymal stem cell-derived exosomes are nanoscale vesicles secreted by cells with a double-layered membrane structure, which can exert direct anti-cancer effects through their own signaling molecules or act as drug carriers to enhance the anti-cancer effects of drugs through synergistic effects, drug sensitization, improvement of the immune microenvironment, and improvement of drug resistance. In order to have a more comprehensive understanding of the current research status of exosomes in the treatment of Hepatocellular carcinoma, this review focuses on the latest research related to mesenchymal stem cell-derived exosomes and Hepatocellular carcinoma, with the aim of providing reference for the development of new treatment strategies for Hepatocellular carcinoma.
