Mechanism of action of microorganisms in tumor neoantigen immunotherapy and its application progress
10.3760/cma.j.cn121382-20250430-00035
- VernacularTitle:微生物在肿瘤新抗原免疫治疗中的作用机制及其应用进展
- Author:
Lingyun XU
1
;
Bin SONG
Author Information
1. 上海理工大学健康科学与工程学院，上海 200093
- Keywords:
Immunotherapy;
Microorganisms;
Tumor neoantigen;
Cancer vaccine
- From:
International Journal of Biomedical Engineering
2025;48(5):516-522
- CountryChina
- Language:Chinese
-
Abstract:
Due to its high immunogenicity and tumor specificity, tumor neoantigen has emerged as an important target for tumor immunotherapy. The capacity of microorganisms to modulate the immune system, thereby activating neoantigen-specific T cells and utilizing the phenomenon of molecular mimicry, underscores their potential for broad application in the development of cancer vaccines. In this review, the mechanisms of action of microorganisms in neoantigen immunotherapy were examined, and the applications of bacteria and their derivatives, viral vectors, and fungal vectors in delivering tumor neoantigens were summarized. The significance of microorganisms in tumor neoantigen immunotherapy was underscored, and a reference for future research and clinical application was provided.
