Research progress on the characteristics of γδ T cells in breast cancer patients and their anti-breast cancer mechanism
10.3760/cma.j.cn121382-20250616-00045
- VernacularTitle:γδ T细胞在乳腺癌患者中的特征及其抗乳腺癌作用机制的研究进展
- Author:
Renhong ZHU
1
;
Shicai ZHANG
;
Keqiang WANG
Author Information
1. 泰安市肿瘤医院检验科，泰安 271000
- Keywords:
Breast cancer;
Immunotherapy;
γδ T cells;
Breast cancer stem cells
- From:
International Journal of Biomedical Engineering
2025;48(5):489-500
- CountryChina
- Language:Chinese
-
Abstract:
γδ T cells are a distinct subset of T lymphocytes that demonstrate anti-tumor activity that is not contingent upon conventional major histocompatibility complex-restricted antigen presentation. These cells demonstrate extensive reactivity to anti-breast cancer cells and are capable of exerting anti-breast cancer through mechanisms such as direct cell killing and immune regulation. γδ T cells are a promising type of effector cell that is being developed for the treatment of breast cancer through immunotherapy. Immunotherapy has emerged as a critical treatment modality for patients with postoperative or advanced breast cancer. The activation of γδ T cells in vivo or their use in adoptive cell therapy has emerged as a potential strategy for breast cancer immunotherapy. In this review, research progress on the characteristics of γδ T cells in breast cancer patients and their anti-breast cancer mechanism were summarized.
