Application progress of exosome non-coding RNA in female reproductive system diseases
10.3760/cma.j.cn121382-20250625-00049
- VernacularTitle:外泌体非编码RNA在女性生殖系统疾病中的应用进展
- Author:
Mahemuti MAIREPATI·
1
;
Sailikebai BALIGEN·
;
Zhenjie JU
;
Rongxin ZHU
;
Yonghui JIAO
;
Jiapaer ZEYIDAN·
Author Information
1. 新疆大学生命科学与技术学院 新疆生物资源基因工程重点实验室，乌鲁木齐 830046
- Keywords:
Exosome;
Female reproductive system diseases;
Non-coding RNA;
Diagnostic biomarker
- From:
International Journal of Biomedical Engineering
2025;48(5):473-481
- CountryChina
- Language:Chinese
-
Abstract:
Exosome, as the critical communication carrier secreted by cells, has been demonstrated to carry non-coding RNA (ncRNA) that participate in regulating the onset and progression of various female reproductive system diseases. In this review, the roles of exosome ncRNA (such as microRNA, long ncRNA, and circular RNA) in non-tumor diseases of the female reproductive system were reviewed, including premature ovarian failure, polycystic ovary syndrome, and endometriosis, as well as in female reproductive system tumor diseases such as ovarian cancer, cervical cancer, and endometrial cancer. The theoretical basis and broad application prospects for the development of non-invasive diagnostic markers, prognostic evaluation tools, and potential therapeutic targets based on exosome ncRNA were provided.
