Application progress of chitosan-based composite scaffolds in myocardial repair and regeneration after myocardial infarction
10.3760/cma.j.cn121382-20250106-00004
- VernacularTitle:壳聚糖基复合支架在心肌梗死后心肌修复与再生中的应用进展
- Author:
Nan CHEN
1
;
Jing LIU
;
Qingyu WANG
;
Hailing ZHANG
Author Information
1. 中国医学科学院 北京协和医学院生物医学工程研究所，天津 300192
- Keywords:
Chitosan;
Tissue engineering;
Myocardial infarction;
Myocardial repair;
Myocardial regeneration;
Composite scaffold
- From:
International Journal of Biomedical Engineering
2025;48(4):345-350
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial infarction is a serious type of myocardial ischemic disease. Traditional treatments can only alleviate clinical symptoms and cannot repair damaged myocardium. In this review, the application progress of chitosan-based composite scaffolds in myocardial repair and regeneration after myocardial infarction was reviewed. Combining chitosan with polymers, such as natural proteins and natural polysaccharides can mimic the properties of natural myocardial tissue, reducing ventricular wall stress while increasing biological activity and promoting the retention, repair or regeneration of myocardial cells. Combining chitosan with synthetic polymers and nanomaterials can promote the repair and regeneration of myocardial cells, improve the electrophysiological function of the infarcted area and resynchronise cardiac contraction.
