Research progress of puerarin hydrogel system in tissue regeneration
10.3760/cma.j.cn121382-20250220-00016
- VernacularTitle:葛根素水凝胶体系在组织再生领域的研究进展
- Author:
Peng LI
1
;
Chao WANG
;
Bin SHAO
;
Long JIA
;
Weidong MU
Author Information
1. 滨州医学院附属医院创伤骨科，滨州 256603
- Keywords:
Puerarin;
Tissue regeneration;
Hydrogel;
Biomedicine;
Traditional Chinese medicine
- From:
International Journal of Biomedical Engineering
2025;48(4):338-344
- CountryChina
- Language:Chinese
-
Abstract:
Puerarin is a monomeric isoflavone compound derived from Puerariae Lobatae Radix. It exhibits poor solubility in both water and lipids, resulting in suboptimal oral absorption and low bioavailability. There is therefore an urgent need to develop new methods of applying puerarin to enhance its solubility and bioavailability. Studies have revealed that puerarin possesses distinctive physical and chemical properties, including the ability to self-assemble into supramolecular hydrogels in response to temperature changes. In this review, the research progress of puerarin as a hydrogel system containing loaded drugs, as well as a hydrogel system composed of hydrogel matrix in the field of tissue regeneration was summarized. This is intended to provide a reference for the rational and efficient use of drugs and lay the groundwork for the development and preparation of new drug carrier platforms.
