Research progress on the formation mechanism of dynamic hydrogel and its applications in bone repair therapy
10.3760/cma.j.cn121382-20241031-00130
- VernacularTitle:动态水凝胶的形成机制及其在骨修复治疗方面应用的研究进展
- Author:
Ruirui DING
1
;
Yuwen WANG
;
Lingrong LIU
Author Information
1. 中国医学科学院 北京协和医学院生物医学工程研究所，天津 300192
- Keywords:
Hydrogel;
Bone defects;
Formation mechanism;
Bone repair therapy;
Reversible cross-linked
- From:
International Journal of Biomedical Engineering
2025;48(4):327-337
- CountryChina
- Language:Chinese
-
Abstract:
Dynamic hydrogel is three-dimensional networks of hydrophilic polymer formed by dynamic reversible cross-linked bonds. It is widely used in the field of bone repair therapy. The dynamic reversible cross-linked bonds in the dynamic hydrogel endows it with shear-thinning rheological properties, resulting in excellent self-healing, injectability and tunable mechanical properties. In this review, the formation mechanism of dynamic hydrogel was summarized, including non-covalent interaction and dynamic covalent interaction. The advantages and disadvantages of the various cross-linked methods used to form dynamic hydrogel were discussed. The applications of dynamic hydrogel in bone repair therapy were summarized, including haemostasis for filling bone defects, drug delivery, modulation of stem cell behavior, and biomimetic mineralization, to provide a reference for the future development of dynamic hydrogel for bone repair therapy.
