Application progress of biomineralization in drug delivery
10.3760/cma.j.cn121382-20241101-00134
- VernacularTitle:生物矿化在药物递送中的应用进展
- Author:
Yifan ZHANG
1
;
Linhua ZHANG
;
Dunwan ZHU
Author Information
1. 中国医学科学院 北京协和医学院生物医学工程研究所，天津 300192
- Keywords:
Biomineralization;
Biomimetic synthesis;
Nanomaterial;
Drug delivery
- From:
International Journal of Biomedical Engineering
2025;48(4):321-326
- CountryChina
- Language:Chinese
-
Abstract:
Biomineralization is a unique process for generating biominerals and has become a popular area of research in biomedical materials due to its excellent biocompatibility and biodegradability, as well as the simple and economical synthesis process. In this review, the fundamental concepts of biomineralization and the principles of organic matrix-induced nucleation were introduced. According to the biomimetic mineralization technology mediated by matrices such as proteins and their derivatives, nucleic acids, nanozymes, polysaccharides, organisms, polymers and metal-organic frameworks, the application progress of biomineralization technology to drug delivery by protecting active molecules, constructing drug carriers and responding to acidic environments was reviewed. The difficult problems to be solved were also summarized.
