Research progress in hydrogel-based cell mechanics and related detection technology
10.3760/cma.j.cn121382-20241221-00163
- VernacularTitle:基于水凝胶的细胞力学及相关检测技术的研究进展
- Author:
Ruirui DING
1
;
Yuwen WANG
;
Zhe WANG
;
Lingrong LIU
Author Information
1. 中国医学科学院 北京协和医学院生物医学工程研究所，天津 300192
- Keywords:
Hydrogel;
Cell mechanics;
Matrix stiffness;
Mechanical microenvironment;
Mechanical factor
- From:
International Journal of Biomedical Engineering
2025;48(3):303-312
- CountryChina
- Language:Chinese
-
Abstract:
In vivo, cells exist within the mechanical microenvironment of the extracellular matrix (ECM), and their biological processes are regulated by various mechanical factors. However, existing technology limits the direct study of the interaction between cells and ECM in vivo. Using hydrogel to mimic the natural ECM and to construct a suitable mechanical microenvironment for isolated cells, which indirectly reflects the cell-ECM interactions in real organisms through in vitro studies. Thus, in this review, the effects of mechanical factors in hydrogel on different types of cells were summarized, and the development of cell mechanical detection technology using hydrogel as carriers was introduced. Moreover, the future work of using hydrogel to study cell mechanical behavior and related detection technology, as well as standardized preparation, was discussed.
