Research progress in chimeric antigen receptor regulatory T cells in autoimmune diseases

VernacularTitle:嵌合抗原受体调节性T细胞在自身免疫性疾病中的研究进展
Author: Juntao XIE ¹ ; Lin MEI
Author Information

1. 中国医学科学院　北京协和医学院生物医学工程研究所　先进医用材料与医疗器械全国重点实验室　天津市生物医学材料重点实验室，天津　300192
Keywords: Chimeric antigen receptor; Regulatory T cells; Autoimmune diseases; Treg cells
From: International Journal of Biomedical Engineering 2025;48(3):295-302
CountryChina
Language:Chinese
Abstract: Regulatory T (Treg) cells are essential for maintaining immune tolerance, and the decreased numbers or dysfunction of these cells can lead to autoimmune diseases (AIDs). Clinical trials have proven that adoptive Treg cells therapy can relieve AIDs. Advancements in chimeric antigen receptor (CAR) technology have prompted the expansion of Treg cells for adoptive Treg cells therapy, thereby generating CAR-Treg cells and providing a novel therapeutic strategy for AIDs. In this review, the structure, functions, preparation methods, mechanisms, and applications in seven common AIDs of CAR-Treg cells were summarized, and the future development direction was prospected.