Application progress in nano delivery systems based on pullulan and its derivatives in cancer treatment
10.3760/cma.j.cn121382-20241025-00128
- VernacularTitle:基于普鲁兰及其衍生物的纳米递送系统在癌症治疗中的应用进展
- Author:
Shamei LUO
1
;
Dunwan ZHU
;
Linhua ZHANG
Author Information
1. 中国医学科学院 北京协和医学院生物医学工程研究所，天津 300192
- Keywords:
Nanotechnology;
Nano delivery systems;
Pullulan;
Cancer treatment;
Biological responsiveness;
Gene delivery
- From:
International Journal of Biomedical Engineering
2025;48(3):225-231
- CountryChina
- Language:Chinese
-
Abstract:
Pullulan, a natural polysaccharide, has good biocompatibility and biodegradability. Pullulan and its derivatives show broad application prospects in tumor-targeted delivery and therapy. In this review, various nano delivery systems based on pullulan and its derivatives were reviewed. Among them, pullulan-related nanogels, nanoparticles, and nanomicelles can enhance the targeting and penetration of chemotherapeutic drugs while reducing toxicity to normal tissues, pullulan-related gene nano delivery systems can show good performance and improve gene transfection efficiency, and pullulan-related bioresponsive nano delivery systems can further enhance therapeutic efficacy while avoiding multidrug resistance.
