Research progress in synthesis methods of manganese-based nanomaterials and their applications in tumor immunotherapy
10.3760/cma.j.cn121382-20250410-00027
- VernacularTitle:锰基纳米材料的合成方法及其在肿瘤免疫治疗中应用的研究进展
- Author:
Na LI
1
;
Qianqian LIU
;
Caihao HUANG
;
Liang LU
;
Zeping ZHANG
;
Xing ZHANG
Author Information
1. 沈阳大学生命科学与工程学院，沈阳 110044
- Keywords:
Nanomaterials;
Manganese-based materials;
Immunotherapy;
Tumor microenvironment;
Magnetic resonance imaging
- From:
International Journal of Biomedical Engineering
2025;48(3):217-224
- CountryChina
- Language:Chinese
-
Abstract:
Due to their unique physicochemical properties, nanomaterials can optimize drug delivery and reshape the tumor microenvironment. Manganese-based nanomaterials are primarily used in tumor immunotherapy for the following purpose, including targeted activating of the cyclic GMP-AMP synthase-stimulator of interferon gene pathway to enhance immunogenicity, utilizating of manganese′s redox properties to regulate the tumor microenvironment, and developing of manganese-based magnetic resonance imaging contrast agents to monitor immune responses in real time. In this review, synthesis methods of manganese-based nanomaterials such as thermal decomposition method, hydrothermal/solvothermal synthesis method, and chemical precipitation/mixing method as well as an in-depth analysis of their applications in tumor immunotherapy including immune regulation, regulation of tumor microenvironment and enhanced magnetic resonance imaging were reviewed.
