Application progress of nanotechnology in chimeric antigen receptor T cell immuno-therapy
10.3760/cma.j.cn121382-20241206-00153
- VernacularTitle:纳米技术在嵌合抗原受体T细胞免疫治疗中的应用进展
- Author:
Yijie ZHAN
1
;
Lanxia LIU
Author Information
1. 中国医学科学院 北京协和医学院生物医学工程研究所，天津 300192
- Keywords:
Chimeric antigen receptor T cell immuno-therapy;
Nanotechnology;
Tumor microenvironment;
Delivery carrier;
Antigen target;
Solid tumor
- From:
International Journal of Biomedical Engineering
2025;48(3):212-216
- CountryChina
- Language:Chinese
-
Abstract:
Chimeric antigen receptor T cell immuno-therapy (CAR-T) has achieved remarkable results in treating hematological malignancies by targeted killing of tumor by gene-edited T cells. However, it faces challenges such as target antigen deletion, tumor heterogeneity, and an immunosuppressive microenvironment when applied to solid tumors. Nanocarriers, as a new carrier system, can effectively improve the therapeutic effect of CAR-T and reduce its toxicity. In this review, the application progress of nanotechnology in CAR-T was summarized, such as using nanoparticles (NPs) to delivery mRNA CAR and provide antigen targets for CAR-T, and nanocarriers improve the tumor microenvironment. These techniques provide a new strategy for achieving efficient, personalized CAR-T immunotherapy in solid tumors.
