Research progress on survival stress of non-diploid cells and their role in tumor cells
10.3760/cma.j.cn121382-20250102-00212
- VernacularTitle:非二倍体细胞的生存应激及其在肿瘤细胞中作用的研究进展
- Author:
Jing SUN
1
;
Jinyan GONG
;
Dan SHA
Author Information
1. 山东中医药大学第二临床医学院，济南 250014
- Keywords:
Diploid;
DNA ploidy;
Tumor;
Survival stress
- From:
International Journal of Biomedical Engineering
2025;48(2):190-196
- CountryChina
- Language:Chinese
-
Abstract:
The alteration of DNA content in tumor cells is called DNA ploidy. The normal DNA content is called diploid, while the abnormal DNA content is called non-diploid, which includes polyploid and aneuploid. Non-diploid status leads to survival stress in tumor cells, including genomic stress, protein toxicity stress, metabolic stress, and immune stress, and plays a dual role by both inhibiting and promoting tumor development. In this review, the survival stress of non-diploid cells and their role in tumor cells were summarized to provide a potential target for disease intervention and provide a reference for early screening, precision prevention, and personalized treatment.
