Advances in preparation of carrier-free self-assembled nanodrugs and their application in cancer therapy
10.3760/cma.j.cn121382-20240929-00203
- VernacularTitle:无载体自组装纳米药物的制备及其在癌症治疗中的应用进展
- Author:
Shamei LUO
1
;
Dunwan ZHU
;
Linhua ZHANG
Author Information
1. 中国医学科学院 北京协和医学院生物医学工程研究所，天津 300192
- Keywords:
Nanodrug;
Drug delivery systems;
Carrier-free;
Self-assemble;
Cancer therapy
- From:
International Journal of Biomedical Engineering
2025;48(2):118-123
- CountryChina
- Language:Chinese
-
Abstract:
Carrier-free self-assembled nanodrugs show broad application prospects in cancer treatment. Compared with carrier-based nanodrugs, carrier-free self-assembled nanodrugs have the advantages of strong targeting ability and high safety, which can significantly improve the therapeutic efficacy against cancer. Their preparation process is simple, involving a variety of non-covalent interactions, and they exhibit better biocompatibility and immune effects in vaccine development. Carrier-free self-assembled nanodrugs can be divided into nanodrugs based on prodrugs, free drugs, and amphiphilic drug conjugates. In this review, the preparation methods of these three types of carrier-free self-assembled nanodrugs and their research progress in cancer treatment in recent years were summarized, and their clinical applications and future prospects were discussed.
