Research progress in surface modification strategies for blood purification materials
10.3760/cma.j.cn121382-20241108-00114
- VernacularTitle:血液净化材料表面改性策略的研究进展
- Author:
Di HE
1
;
Juanjuan LIU
;
Weihua YIN
;
Fengjie HAN
;
Guiming SHU
Author Information
1. 天津医科大学第三临床医学院，天津 300170
- Keywords:
Blood purification materials;
Anticoagulation;
Surface modification
- From:
International Journal of Biomedical Engineering
2025;48(1):96-102
- CountryChina
- Language:Chinese
-
Abstract:
The development of blood purification materials has progressed from cellulose membranes to high-strength polymer membranes, but the blood compatibility of the membranes remains a major challenge for their clinical applications. In this review, blood purification materials were categorized according to the commonly used material surface modification strategies, including surface grafting of anticoagulant groups, surface coating of materials and electrostatic layer-by-layer self-assembly, covalent attachment of superhydrophilic hydrogels, and blending method. Anticoagulant properties such as clotting time and surface hydrophilicity of various blood purification materials were also discussed to further analyze the value and challenges of blood purification materials in clinical practice.
