Application progress of intestinal organoids in the study of inflammatory bowel disease
10.3760/cma.j.cn121382-20241120-00113
- VernacularTitle:肠道类器官在炎症性肠病研究中的应用进展
- Author:
Jinyao LIU
1
;
Peizhao LIU
;
Yun ZHAO
Author Information
1. 南京医科大学附属明基医院外科实验室，南京 210019
- Keywords:
Inflammatory bowel disease;
Intestinal organoids;
Mechanism research;
Drug screening;
Intestinal mucosal repair
- From:
International Journal of Biomedical Engineering
2025;48(1):88-95
- CountryChina
- Language:Chinese
-
Abstract:
The aetiology of inflammatory bowel disease (IBD) involves genetic, immunological and microbiological factors, and the specific mechanisms of which are not yet fully understood. Intestinal organoids have an important role to play in the study of IBD, particularly with regard to mechanical barrier damage to the intestinal epithelium, intestinal micro-ecological dysregulation and genetic mechanisms. Intestinal organoids can also be used for screening of IBD therapeutics and individualized treatment monitoring in IBD, and are expected to cure IBD by means of repairing the intestinal mucosa or by transplantation. The application of intestinal organoids faces standardization, ethical, legal and technical challenges. However, with the improvement of standardization and technological advancement, it is expected to be combined with technologies such as artificial intelligence to further elucidate the pathogenesis of IBD and promote treatment innovation.
