Construction of intelligent engineering bacteria and its research progress in diagnosis and treatment of disease
10.3760/cma.j.cn121382-20240901-00104
- VernacularTitle:智能工程菌的构建及其在疾病诊疗中的研究进展
- Author:
Junwei CHEN
1
;
Feiyang HU
;
Jiacheng WEN
;
Fucheng HE
;
Yaxue DING
;
Liangbin XIONG
Author Information
1. 上海理工大学健康科学与工程学院，上海 200093
- Keywords:
Genetic engineering;
Intelligent engineering bacteria;
Intelligent diagnosis and treatment;
Synthetic biology;
Biosensor system
- From:
International Journal of Biomedical Engineering
2025;48(1):19-27
- CountryChina
- Language:Chinese
-
Abstract:
Microorganisms have high application value in the field of drug development such as antibacterial and anti-tumor. By using genetic engineering to modify microorganisms, intelligent engineering bacteria can be contained that can sense, transmit, compute, and feedback disease signals in real time. In this review, three crucial aspects in the construction of intelligent engineering bacteria were summarized, including the selection of chassis strains, the construction of a biosensor system, and the design of a controlled release mode of functional factors. The clinical applications of intelligent engineering bacteria in the adjunctive diagnosis and treatment of metabolic diseases, inflammatory diseases, tumors, and infectious diseases were further discussed. The challenges and prospects of the current research were also analyzed to provide reference for relevant personnel.
