Research progress of bacteria and their derivatives-mediated tumor therapy
10.3760/cma.j.cn121382-20240711-00602
- VernacularTitle:细菌及其衍生物介导肿瘤治疗的研究进展
- Author:
Xiaohan YANG
1
;
Feng LYU
;
Xia DONG
Author Information
1. 中国医学科学院 北京协和医学院生物医学工程研究所，天津 300192
- Keywords:
Tumor microenvironment;
Bacteria;
Bacterial derivatives;
Bacterial outer membrane vesicles;
Minicells
- From:
International Journal of Biomedical Engineering
2024;47(6):523-529
- CountryChina
- Language:Chinese
-
Abstract:
Bacteria and their derivatives-mediated tumor therapy is an emerging therapeutic strategy. This strategy uses bacteria or bacterial derivatives as drug carriers to deliver drugs to tumor tissues through the targeting and motility of bacteria or bacterial derivatives and utilizes their special biological characteristics to cooperate with other therapies. In this review, the mechanism and advantages of bacteria-mediated tumor therapy were summarized, focusing on the combined application of bacterial therapy and chemotherapy, photothermal therapy, and radiotherapy, which improves the therapeutic effect through a synergistic effect. At the same time, the characteristics, structure, and composition of bacterial derivatives of bacterial outer membrane vesicles (OMVs) and minicells and their application in tumor therapy were also summarized. Although there are still some problems to be solved in the treatment of tumors mediated by bacteria and their derivatives, their potential to colonize in tumors and induce immune responses cannot be ignored. This therapy also provides new ideas for tumor therapy.
