Ambient temperature affects the risk of ischemic stroke: the possible mechanisms
10.3760/cma.j.issn.1673-4165.2025.07.006
- VernacularTitle:环境温度影响缺血性卒中风险的可能机制
- Author:
Yuhan DU
1
;
Shaoling LI
;
Jingjing CAI
;
Lijie REN
Author Information
1. 深圳市第二人民医院神经内科，深圳 518035
- Keywords:
Ischemic stroke;
Temperature;
Hot temperature;
Extreme heat;
Cold temperature;
Risk factors;
Seasons
- From:
International Journal of Cerebrovascular Diseases
2025;33(7):534-538
- CountryChina
- Language:Chinese
-
Abstract:
Epidemiological investigations and clinical studies have shown that inappropriate ambient temperatures (high and low temperatures) are the independent risk factors for ischemic stroke, but their underlying physiological mechanisms are not fully understood. This article systematically reviews the potential mechanisms by which inappropriate ambient temperatures promote the occurrence of ischemic stroke through multiple pathways, such as activating the sympathetic-renin-angiotensin system, inducing systemic inflammation and oxidative stress, damaging the integrity of the intestinal barrier and blood-brain barrier, and disrupting coagulation-fibrinolysis balance.
