Roles of the glymphatic system in ischemic stroke
10.3760/cma.j.issn.1673-4165.2025.07.005
- VernacularTitle:胶质淋巴系统在缺血性卒中中的作用
- Author:
Danli QIU
1
;
Shenghai GAO
;
Lingyu ZHANG
;
Honghong JI
;
Pengfei WANG
Author Information
1. 山东第二医科大学临床学院，潍坊 261000
- Keywords:
Ischemic stroke;
Glymphatic system;
Diffusion tensor imaging;
Brain edema;
Cognitive dysfunction;
Epilepsy
- From:
International Journal of Cerebrovascular Diseases
2025;33(7):528-533
- CountryChina
- Language:Chinese
-
Abstract:
The glymphatic system is an important pathway for fluid drainage and metabolic waste clearance in the central nervous system. Its core mechanism involves the active cerebrospinal fluid-interstitial fluid circulation process mediated by perivascular spaces and aquaporin-4 channels located on astrocytic endfeet. This process is crucial for eliminating neurotoxic substances such as β-amyloid and tau proteins, as well as maintaining homeostasis in the central nervous system. Recent studies have shown that dynamic changes in the glymphatic system are associated with recovery after ischemic stroke. This article elaborates on the role of the glymphatic system in ischemic stroke and evaluates its potential value as a novel therapeutic target, providing new insights for post-stroke treatment strategies.
