Pathophysiological mechanisms of secondary white matter injury after ischemic stroke
10.3760/cma.j.issn.1673-4165.2025.06.011
- VernacularTitle:缺血性卒中后继发白质损伤的病理生理学机制
- Author:
Min LIU
1
;
Chao HOU
;
Zhenqian HUANG
;
Wusheng ZHU
;
Ruidong YE
Author Information
1. 南京医科大学金陵临床医学院，南京 210002
- Keywords:
Ischemic stroke;
Brain ischemia;
Brain injuries;
White matter;
Inflammation;
Immunity;
Blood-brain barrier;
Mitochondria;
Oligodendroglia;
Remyelination
- From:
International Journal of Cerebrovascular Diseases
2025;33(6):468-472
- CountryChina
- Language:Chinese
-
Abstract:
Secondary white matter injury after ischemic stroke refers to the secondary changes in the white matter structure outside the infarct site that are not directly damaged after stroke, often involving key connecting areas such as the corpus callosum and contralateral internal capsule. This injury is closely associated with post-stroke cognitive impairment, motor dysfunction, and language disorders, which affects the long-term outcome. Its pathophysiological mechanisms mainly include immune and inflammatory imbalance, excitotoxicity and mitochondrial dysfunction, blood-brain barrier damage, axonal injury, and remyelination disorder. Exploring these mechanisms in depth can help promote early diagnosis and intervention of secondary white matter damage after ischemic stroke, provide theoretical basis for the development of targeted treatment strategies, and promote functional recovery in patients with stroke.
