Effect of blood lipids and statins use on the outcome of acute ischemic stroke patients with cerebral microbleeds
10.3760/cma.j.issn.1673-4165.2025.06.003
- VernacularTitle:血脂和他汀类药物使用对合并脑微出血的急性缺血性卒中患者转归的影响
- Author:
Haibin SHENG
1
;
Liyan SONG
;
Wanqing ZHAI
;
Yi ZHOU
Author Information
1. 江苏省太仓市第一人民医院神经内科，苏州 215400
- Keywords:
Ischemic stroke;
Cerebral hemorrhage;
Magnetic resonance imaging;
Lipids;
Hydroxymethylglutaryl-CoA reductase inhibitors;
Treatment outcome;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2025;33(6):414-419
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of blood lipids and statins use on the outcome of acute ischemic stroke (AIS) patients with cerebral microbleeds (CMBs).Methods:Consecutive AIS patients with CMBs hospitalized at the First People's Hospital of Taicang, Jiangsu Province from July 2023 to June 2024 were included retrospectively. At 3 months after onset, the modified Rankin Scale was used for outcome assessment. 0-2 was defined as good outcome and >2 was defined as poor outcome. Multivariate logistic regression analysis was used to identify independent influencing factors for poor outcome. Results:A total of 110 AIS patients with CMBs were enrolled, including 72 males (65.5%), aged 68.04±3.12 years. Thirty patients (27.3%) had poor outcome. Univariate analysis showed that age, baseline National Institutes of Health Stroke Scale (NIHSS) score, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and the proportion of patients with hypertension and diabetes in poor outcome group were significantly higher than those in good outcome group, while baseline high-density lipoprotein cholesterol and the proportion of patients using statins before onset were significantly lower than those in good outcome group ( P<0.05). Multivariate logistic regression analysis showed that age (odds ratio [ OR] 1.309, 95% confidence interval [ CI] 1.007-1.702; P=0.044), the baseline NIHSS score ( OR 1.541, 95% CI 1.143-2.078; P=0.005) and high triglycerides ( OR 5.150, 95% CI 2.150-8.717; P=0.023) were the independent risk factors for poor outcome, while high high-density lipoprotein cholesterol ( OR 0.001, 95% CI 0.001-0.034; P<0.001) and statins use ( OR 0.231, 95% CI 0.046-0.558; P=0.019) were the independent protective factors for good outcome. Conclusions:Blood lipid and statins use are independent influencing factors for the outcome of AIS patients with CMBs. The use of statins before onset is associated with a lower risk of poor outcome in AIS patients with CMBs.
