Correlation between serum inflammatory markers and early neurological deterioration in patients with minor ischemic stroke
10.3760/cma.j.issn.1673-4165.2025.06.002
- VernacularTitle:血清炎症标志物与轻型缺血性卒中患者早期神经功能恶化的相关性
- Author:
Minyan LU
1
;
Li ZHOU
;
Zhiqiang QI
Author Information
1. 南京医科大学附属江苏盛泽医院神经内科，苏州 215228
- Keywords:
Ischemic stroke;
Severity of illness index;
Disease progression;
Inflammation;
Cytokines;
Interleukin-6;
Interleukin-10;
C-reactive protein;
Risk factors;
Biom
- From:
International Journal of Cerebrovascular Diseases
2025;33(6):407-413
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between serum inflammatory markers and early neurological deterioration (END) in patients with minor ischemic stroke (MIS).Methods:Patients with MIS admitted to the Department of Neurology, Jiangsu Shengze Hospital between October 2023 and October 2024 were included retrospectively. MIS was defined as baseline National Institutes of Health Stroke Scale (NIHSS) score ≤5. END was defined as an increase of ≥2 in NIHSS score compared to baseline within 7 days of onset. Multivariate logistic regression analysis was used to determine the independent correlation factors of END. Results:A total of 193 patients with MIS were enrolled, including 126 males (65.3%), aged 68.00±12.42 years, with a median baseline NIHSS score of 1(interquartile range, 1-3). Fifty-six patients (29.0%) experienced END. Univariate analysis showed that uric acid, fasting blood glucose, total cholesterol, low-density lipoprotein cholesterol, interleukin (IL) -6, neutrophil count, and the proportion of patients with atrial fibrillation, large artery atherosclerosis and anticoagulant therapy in the END group were significantly higher than those in the non-END group, while the proportion of patients with etiology as small vessel occlusion and receiving antiplatelet therapy was significantly lower than those in the non-END group (all P<0.05). Multivariate logistic regression analysis showed that higher systolic blood pressure (odds ratio [ OR] 1.031, 95% confidence interval [ CI] 1.008-1.053; P=0.007), hypersensitive C-reactive protein ( OR 1.194, 95% CI 1.076-1.324; P=0.001) and IL-6 ( OR 2.095, 95% CI 1.378-3.184; P=0.001) were the independent risk factors for END, while higher IL-10 ( OR 0.606, 95% CI 0.473-0.775; P=0.001) was an independent protective factor for END. Compared with large artery atherosclerotic stroke, the risk of END in small vessel occlusion stroke was significantly lower ( OR 0.576, 95% CI 0.366-0.906; P=0.007). Conclusion:Higher baseline systolic blood pressure, high-sensitivity C-reactive protein and IL-6, and lower IL-10 are the independent risk factors for END in patients with MIS.
