Lipid metabolic reprogramming of microglia and its impact on neuroinflammation regulation after ischemic stroke
10.3760/cma.j.issn.1673-4165.2025.05.008
- VernacularTitle:缺血性卒中后小胶质细胞脂质代谢重编程及其对神经炎症调控的影响
- Author:
Yingying XUE
1
;
Qian LI
;
Xuemei CHEN
Author Information
1. 南京医科大学附属江宁医院神经内科，南京 211100
- Keywords:
Ischemic stroke;
Brain ischemia;
Lipid metabolism;
Lipid droplets;
Microglia;
Cellular reprogramming;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2025;33(5):366-370
- CountryChina
- Language:Chinese
-
Abstract:
After the onset of ischemic stroke, microglia undergo lipid metabolic reprogramming, especially lipid droplet accumulation, which significantly affects their polarization state and inflammatory response. Lipid droplets can exacerbate neuroinflammation by synthesizing inflammatory lipid mediators, and may also have a protective effect under certain conditions. Its metabolic reprogramming involves multiple pathway regulation such as fatty acid oxidation and cholesterol efflux. This article reviews the mechanism of changes in lipid droplet metabolism of microglia and its role in the pathological process after stroke, aiming to provide new ideas for metabolic intervention strategies.
