Application of nanomaterials in the diagnosis and treatment of ischemic stroke
10.3760/cma.j.issn.1673-4165.2025.05.006
- VernacularTitle:纳米材料在缺血性卒中诊断与治疗中的应用
- Author:
Yanqin FAN
1
;
Liming CAO
Author Information
1. 深圳大学医学部，深圳 518060
- Keywords:
Ischemic stroke;
Brain ischemia;
Nanotechnology;
Nanostructures;
Nanoparticles;
Nanoparticle drug delivery system;
Tomography, X-ray computed;
Magnetic reson
- From:
International Journal of Cerebrovascular Diseases
2025;33(5):356-361
- CountryChina
- Language:Chinese
-
Abstract:
The traditional diagnosis and treatment mode of ischemic stroke faces challenges such as limited diagnostic time window, insufficient drug targeting, and difficulty in penetrating the blood-brain barrier. Nanomaterials, with their unique physicochemical properties and biological effects, provide innovative solutions for precise diagnosis and treatment. In terms of diagnosis, targeted thrombus nanoprobes constructed from nanomaterials, combined with MRI or CT, can achieve high sensitivity and visual detection of thrombi. The development of nano-biosensors has significantly improved the detection efficiency and accuracy of specific biomarkers for ischemic stroke. In terms of treatment, nano-drug carrier systems can efficiently load thrombolytic drugs and promote their penetration of the blood-brain barrier, achieving targeted delivery. Biomimetic nanoparticles effectively promote angiogenesis and neurological function repair in ischemic brain regions by regulating inflammation and oxidative stress. This article systematically reviews the application progress of nanomaterials in the diagnosis and treatment of ischemic stroke, aiming to provide a basis for promoting the translation of nanotechnology from basic research to clinical practice, and to provide new ideas for precise diagnosis and treatment of ischemic stroke.
