Correlation between body mass index to high-density lipoprotein cholesterol ratio and cerebral small vessel disease in middle-aged and elderly people
10.3760/cma.j.issn.1673-4165.2025.05.005
- VernacularTitle:体重指数/高密度脂蛋白胆固醇比值与中老年人脑小血管病的相关性
- Author:
Meng CAO
1
;
Cunsheng WEI
;
Junying JIANG
;
Yingying XUE
;
Ying SHE
;
Xuemei CHEN
Author Information
1. 南京大学医学院附属泰康仙林鼓楼医院神经内科，南京 210046
- Keywords:
Cerebral small vessel diseases;
Body mass index;
Cholesterol, HDL;
Metabolic syndrome;
Risk factors;
Biomarkers
- From:
International Journal of Cerebrovascular Diseases
2025;33(5):350-355
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between body mass index (BMI)/high-density lipoprotein cholesterol (HDL-C) ratio and cerebral small vessel disease (CSVD) in middle-aged and elderly people.Methods:Consecutive middle-aged and elderly patients (aged ≥40 years) who were hospitalized for chronic disease examinations in the Department of Neurology, Jiangning Hospital Affiliated to Nanjing Medical University between February 2022 and May 2024 were included prospectively. According to the overall burden score of CSVD, they were divided into CSVD group (≥1) and non-CSVD group (0). According to age, they divided into middle-aged group (40-59 years old) and elderly group (≥60 years old). The demographic characteristics and clinical data were collected. Binary multivariate logistic regression analysis was used to determine the independent correlation between BMI/HDL-C ratio and CSVD. Forest plot was used to analyze the correlation between BMI/HDL-C ratio and CSVD in different age groups. Results:A total of 710 patients were included, with an age of 66.0±10.0 years and 361 were males (50.8%). There were 261 patients (36.8%) in the CSVD group and 449 (63.2%) in the non-CSVD group. The BMI/HDL-C ratio in the CSVD group was significantly higher than that in the non-CSVD group (23.60±7.00 vs. 20.78±6.40; P<0.001). Multivariate logistic regression analysis showed that BMI/HDL-C ratio was an independent risk factor for CSVD in middle-aged and elderly populations (odds ratio 1.046, 95% confidence interval 1.027-1.064; P<0.001). There were 475 patients in the elderly group, of which 198 (41.7%) had CSVD; there were 235 patients in the middle-aged group, of which 63 (26.8%) had CSVD. Forest plot analysis showed that the association between BMI/HDL-C ratio and CSVD still had statistical significance in different age groups, but the effect intensity was higher in the elderly group than in the middle-aged group. Conclusion:The BMI/HDL-C ratio is independently correlated with CSVD in middle-aged and elderly population, particularly significant in the elderly population.
