Roles and mechanisms of pyroptosis in early brain injury following subarachnoid hemorrhage
10.3760/cma.j.issn.1673-4165.2025.04.012
- VernacularTitle:细胞焦亡在蛛网膜下腔出血后早期脑损伤中的作用和机制
- Author:
Baihao ZHANG
1
;
Yong SUN
Author Information
1. 徐州医科大学附属连云港医院神经外科，连云港 222000
- Keywords:
Subarachnoid hemorrhage;
Brain injuries;
Brain edema;
Pyroptosis;
Inflammasomes;
Inflammation;
Signal Transduction
- From:
International Journal of Cerebrovascular Diseases
2025;33(4):304-310
- CountryChina
- Language:Chinese
-
Abstract:
Early brain injury (EBI) after subarachnoid hemorrhage (SAH) is associated with poor outcome. Pyroptosis activates classical, atypical, and other pathways by inducing the formation of membrane pores and releasing pro-inflammatory factors. In EBI after SAH, pyroptosis occurs in neurons, microglia, endothelial cells and astrocytes, and its regulatory mechanism involves multiple pathways. This article reviews the molecular mechanisms and pharmacological interventions of pyroptosis in EBI after SAH, aiming to provide reference for clinical and basic research.
