Association of serum γ-glutamyltransferase with stroke severity and outcome in patients with acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2025.04.002
- VernacularTitle:血清γ-谷氨酰转移酶与急性缺血性卒中患者卒中严重程度和转归的相关性
- Author:
Ruining DAI
1
;
Xufei HOU
;
Run MIAO
;
Aimei WU
;
Chi ZHANG
;
Ping WANG
Author Information
1. 安徽医科大学附属合肥医院（合肥市第二人民医院）神经内科，合肥 230011
- Keywords:
Ischemic stroke;
γ-Glutamyltransferase;
Severity of illness index;
Treatment outcome;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2025;33(4):246-251
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of serum γ-glutamyltransferase (GGT) with stroke severity and outcome in patients with acute ischemic stroke (AIS).Methods:Patients with AIS admitted to the Department of Neurology, Hefei Second People's Hospital (Guangde Road Branch) from January 2023 to December 2023 were included retrospectively. According to the baseline National Institutes of Health Stroke Scale score, the patients were divided into mild stroke group (≤8) and moderate to severe stroke group (>8); According to the modified Rankin Scale score at 3 months after onset, the patients were divided into a good outcome group (0-2) and a poor outcome group (>2). Multivariate logistic regression analysis was used to determine the independent influencing factors of stroke severity and outcome, and the receiver operating characteristic (ROC) curve was used to evaluate the predictive value of serum GGT for poor outcome. Results:A total of 136 patients with AIS were included, with 42 patients (30.88%) in the mild stroke group and 94 (69.12%) in the moderate to severe stroke group; 80 patients (58.82%) in the good outcome group and 56 (41.18%) in the poor outcome group. Multivariate logistic regression analysis showed that higher serum GGT was an independent related factor for moderate to severe stroke (odds ratio [ OR] 1.075, 95% confidence interval [ CI] 1.017-1.135; P<0.05) and poor outcome ( OR 1.131, 95% CI 1.069-1.197; P<0.05). The ROC curve analysis showed that the area under the curve for predicting poor outcome by serum GGT was 0.820 (95% CI 0.747-0.892). Conclusion:Serum GGT is significantly correlated with the severity of stroke in patients with AIS, and has certain predictive value for poor short-term outcome.
